Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
Identifieur interne : 000149 ( France/Analysis ); précédent : 000148; suivant : 000150Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
Auteurs : Marie-Christine Chartier-Harlin [France] ; Justus C. Dachsel [États-Unis] ; Carles Vilari O-Güell [Canada] ; Sarah J. Lincoln [États-Unis] ; Frédéric Leprêtre [France] ; Mary M. Hulihan [États-Unis] ; Jennifer Kachergus [États-Unis] ; Austen J. Milnerwood [Canada] ; Lucia Tapia [Canada] ; Mee-Sook Song [Canada] ; Emilie Le Rhun [France] ; Eugénie Mutez [France] ; Lydie Larvor [France] ; Aurélie Duflot [France] ; Christel Vanbesien-Mailliot [France] ; Alexandre Kreisler [France] ; Owen A. Ross [États-Unis] ; Kenya Nishioka [États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Stephanie A. Cobb [États-Unis] ; Heather L. Melrose [États-Unis] ; Bahareh Behrouz [États-Unis] ; Brett H. Keeling [États-Unis] ; Justin A. Bacon [États-Unis] ; Emna Hentati [États-Unis] ; Lindsey Williams [États-Unis] ; Akiko Yanagiya [Canada] ; Nahum Sonenberg [Canada] ; Paul J. Lockhart [Australie] ; Abba C. Zubair [États-Unis] ; Ryan J. Uitti [États-Unis] ; Jan O. Aasly [Norvège] ; Anna Krygowska-Wajs [Pologne] ; Grzegorz Opala [Pologne] ; Zbigniew K. Wszolek [États-Unis] ; Roberta Frigerio [États-Unis] ; Demetrius M. Maraganore [États-Unis] ; David Gosal [Irlande (pays)] ; Tim Lynch [Irlande (pays)] ; Michael Hutchinson [Irlande (pays)] ; Anna Rita Bentivoglio [Italie] ; Enza Maria Valente [Italie] ; William C. Nichols [États-Unis] ; Nathan Pankratz [États-Unis] ; Tatiana Foroud [États-Unis] ; Rachel A. Gibson [Royaume-Uni] ; Faycal Hentati [Tunisie] ; Dennis W. Dickson [États-Unis] ; Alain Destée [France] ; Matthew J. Farrer [États-Unis, Canada]Source :
- American Journal of Human Genetics [ 0002-9297 ] ; 2011.
Abstract
Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is explained by a missense mutation c.3614G>A (p.Arg1205His) in eukaryotic translation initiation factor 4-gamma (
Url:
DOI: 10.1016/j.ajhg.2011.08.009
PubMed: 21907011
PubMed Central: 3169825
Affiliations:
- Australie, Canada, France, Irlande (pays), Italie, Norvège, Pologne, Royaume-Uni, Tunisie, États-Unis
- Gouvernorat de Tunis, Hauts-de-France, Latium, Nord-Pas-de-Calais, Québec, Trøndelag
- Lille, Montréal, Rome, Trondheim, Tunis
- Université Lille 2, Université Lille Nord de France, Université McGill
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000512
- to stream Pmc, to step Curation: 000512
- to stream Pmc, to step Checkpoint: 000884
- to stream Ncbi, to step Merge: 000F55
- to stream Ncbi, to step Curation: 000F55
- to stream Ncbi, to step Checkpoint: 000F55
- to stream Main, to step Merge: 001626
- to stream Main, to step Curation: 001563
- to stream Main, to step Exploration: 001563
- to stream France, to step Extraction: 000149
Links to Exploration step
PMC:3169825Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Translation Initiator <italic>EIF4G1</italic> Mutations in Familial Parkinson Disease</title><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. 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Milnerwood</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Tapia, Lucia" sort="Tapia, Lucia" uniqKey="Tapia L" first="Lucia" last="Tapia">Lucia Tapia</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Song, Mee Sook" sort="Song, Mee Sook" uniqKey="Song M" first="Mee-Sook" last="Song">Mee-Sook Song</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Le Rhun, Emilie" sort="Le Rhun, Emilie" uniqKey="Le Rhun E" first="Emilie" last="Le Rhun">Emilie Le Rhun</name><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Larvor, Lydie" sort="Larvor, Lydie" uniqKey="Larvor L" first="Lydie" last="Larvor">Lydie Larvor</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Duflot, Aurelie" sort="Duflot, Aurelie" uniqKey="Duflot A" first="Aurélie" last="Duflot">Aurélie Duflot</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Vanbesien Mailliot, Christel" sort="Vanbesien Mailliot, Christel" uniqKey="Vanbesien Mailliot C" first="Christel" last="Vanbesien-Mailliot">Christel Vanbesien-Mailliot</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Université des Sciences et Technologies de Lille (USTL), Department of Neurosciences, Villeneuve d'Ascq, F-59655 France</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Université des Sciences et Technologies de Lille (USTL), Department of Neurosciences, Villeneuve d'Ascq, F-59655 France</wicri:regionArea><wicri:noRegion>59655 France</wicri:noRegion><wicri:noRegion>59655 France</wicri:noRegion></affiliation></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L." last="Melrose">Heather L. Melrose</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Keeling, Brett H" sort="Keeling, Brett H" uniqKey="Keeling B" first="Brett H." last="Keeling">Brett H. Keeling</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Hentati, Emna" sort="Hentati, Emna" uniqKey="Hentati E" first="Emna" last="Hentati">Emna Hentati</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Lindsey" sort="Williams, Lindsey" uniqKey="Williams L" first="Lindsey" last="Williams">Lindsey Williams</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Yanagiya, Akiko" sort="Yanagiya, Akiko" uniqKey="Yanagiya A" first="Akiko" last="Yanagiya">Akiko Yanagiya</name><affiliation wicri:level="4"><nlm:aff id="aff7">Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Sonenberg, Nahum" sort="Sonenberg, Nahum" uniqKey="Sonenberg N" first="Nahum" last="Sonenberg">Nahum Sonenberg</name><affiliation wicri:level="4"><nlm:aff id="aff7">Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lockhart, Paul J" sort="Lockhart, Paul J" uniqKey="Lockhart P" first="Paul J." last="Lockhart">Paul J. Lockhart</name><affiliation wicri:level="1"><nlm:aff id="aff8">Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Zubair, Abba C" sort="Zubair, Abba C" uniqKey="Zubair A" first="Abba C." last="Zubair">Abba C. Zubair</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neurology, St. Olav's Hospital, Trondheim N-7006, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olav's Hospital, Trondheim N-7006</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow 31-358, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow 31-358</wicri:regionArea><wicri:noRegion>Krakow 31-358</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice 40-055, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice 40-055</wicri:regionArea><wicri:noRegion>Katowice 40-055</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Neurology, Mayo Clinic, Rochester, MN 55909, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN 55909</wicri:regionArea><wicri:noRegion>MN 55909</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Neurology, Mayo Clinic, Rochester, MN 55909, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN 55909</wicri:regionArea><wicri:noRegion>MN 55909</wicri:noRegion></affiliation></author><author><name sortKey="Gosal, David" sort="Gosal, David" uniqKey="Gosal D" first="David" last="Gosal">David Gosal</name><affiliation wicri:level="1"><nlm:aff id="aff14">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff14">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author><author><name sortKey="Hutchinson, Michael" sort="Hutchinson, Michael" uniqKey="Hutchinson M" first="Michael" last="Hutchinson">Michael Hutchinson</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Neurology, St Vincent's University Hospital, Dublin 4, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, St Vincent's University Hospital, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="1"><nlm:aff id="aff17">Institute of Neurology, Catholic University, Rome 00168, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, Catholic University, Rome 00168</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="aff18">Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina, 98124 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C." last="Nichols">William C. Nichols</name><affiliation wicri:level="1"><nlm:aff id="aff20">Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea><wicri:noRegion>IN 46202</wicri:noRegion></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea><wicri:noRegion>IN 46202</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, Rachel A" sort="Gibson, Rachel A" uniqKey="Gibson R" first="Rachel A." last="Gibson">Rachel A. Gibson</name><affiliation wicri:level="1"><nlm:aff id="aff22">GlaxoSmithKline Pharmaceuticals, Research and Development, Harlow, Greenford, Hammersmith CM19 5AW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline Pharmaceuticals, Research and Development, Harlow, Greenford, Hammersmith CM19 5AW</wicri:regionArea><wicri:noRegion>Hammersmith CM19 5AW</wicri:noRegion></affiliation></author><author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name><affiliation wicri:level="3"><nlm:aff id="aff23">Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21907011</idno><idno type="pmc">3169825</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169825</idno><idno type="RBID">PMC:3169825</idno><idno type="doi">10.1016/j.ajhg.2011.08.009</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000512</idno><idno type="wicri:Area/Pmc/Curation">000512</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000512</idno><idno type="wicri:Area/Pmc/Checkpoint">000884</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000884</idno><idno type="wicri:Area/Ncbi/Merge">000F55</idno><idno type="wicri:Area/Ncbi/Curation">000F55</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F55</idno><idno type="wicri:Area/Main/Merge">001626</idno><idno type="wicri:Area/Main/Curation">001563</idno><idno type="wicri:Area/Main/Exploration">001563</idno><idno type="wicri:Area/France/Extraction">000149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Translation Initiator <italic>EIF4G1</italic> Mutations in Familial Parkinson Disease</title><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. Lincoln</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Lepretre, Frederic" sort="Lepretre, Frederic" uniqKey="Lepretre F" first="Frédéric" last="Leprêtre">Frédéric Leprêtre</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hulihan, Mary M" sort="Hulihan, Mary M" uniqKey="Hulihan M" first="Mary M." last="Hulihan">Mary M. Hulihan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Kachergus, Jennifer" sort="Kachergus, Jennifer" uniqKey="Kachergus J" first="Jennifer" last="Kachergus">Jennifer Kachergus</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Milnerwood, Austen J" sort="Milnerwood, Austen J" uniqKey="Milnerwood A" first="Austen J." last="Milnerwood">Austen J. Milnerwood</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Tapia, Lucia" sort="Tapia, Lucia" uniqKey="Tapia L" first="Lucia" last="Tapia">Lucia Tapia</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Song, Mee Sook" sort="Song, Mee Sook" uniqKey="Song M" first="Mee-Sook" last="Song">Mee-Sook Song</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Le Rhun, Emilie" sort="Le Rhun, Emilie" uniqKey="Le Rhun E" first="Emilie" last="Le Rhun">Emilie Le Rhun</name><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Larvor, Lydie" sort="Larvor, Lydie" uniqKey="Larvor L" first="Lydie" last="Larvor">Lydie Larvor</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Duflot, Aurelie" sort="Duflot, Aurelie" uniqKey="Duflot A" first="Aurélie" last="Duflot">Aurélie Duflot</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Vanbesien Mailliot, Christel" sort="Vanbesien Mailliot, Christel" uniqKey="Vanbesien Mailliot C" first="Christel" last="Vanbesien-Mailliot">Christel Vanbesien-Mailliot</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Université des Sciences et Technologies de Lille (USTL), Department of Neurosciences, Villeneuve d'Ascq, F-59655 France</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Université des Sciences et Technologies de Lille (USTL), Department of Neurosciences, Villeneuve d'Ascq, F-59655 France</wicri:regionArea><wicri:noRegion>59655 France</wicri:noRegion><wicri:noRegion>59655 France</wicri:noRegion></affiliation></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L." last="Melrose">Heather L. Melrose</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Keeling, Brett H" sort="Keeling, Brett H" uniqKey="Keeling B" first="Brett H." last="Keeling">Brett H. Keeling</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Hentati, Emna" sort="Hentati, Emna" uniqKey="Hentati E" first="Emna" last="Hentati">Emna Hentati</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Lindsey" sort="Williams, Lindsey" uniqKey="Williams L" first="Lindsey" last="Williams">Lindsey Williams</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Yanagiya, Akiko" sort="Yanagiya, Akiko" uniqKey="Yanagiya A" first="Akiko" last="Yanagiya">Akiko Yanagiya</name><affiliation wicri:level="4"><nlm:aff id="aff7">Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Sonenberg, Nahum" sort="Sonenberg, Nahum" uniqKey="Sonenberg N" first="Nahum" last="Sonenberg">Nahum Sonenberg</name><affiliation wicri:level="4"><nlm:aff id="aff7">Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 3R1</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Lockhart, Paul J" sort="Lockhart, Paul J" uniqKey="Lockhart P" first="Paul J." last="Lockhart">Paul J. Lockhart</name><affiliation wicri:level="1"><nlm:aff id="aff8">Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Zubair, Abba C" sort="Zubair, Abba C" uniqKey="Zubair A" first="Abba C." last="Zubair">Abba C. Zubair</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Neurology, St. Olav's Hospital, Trondheim N-7006, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olav's Hospital, Trondheim N-7006</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow 31-358, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow 31-358</wicri:regionArea><wicri:noRegion>Krakow 31-358</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="aff12">Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice 40-055, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice 40-055</wicri:regionArea><wicri:noRegion>Katowice 40-055</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Neurology, Mayo Clinic, Rochester, MN 55909, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN 55909</wicri:regionArea><wicri:noRegion>MN 55909</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Neurology, Mayo Clinic, Rochester, MN 55909, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN 55909</wicri:regionArea><wicri:noRegion>MN 55909</wicri:noRegion></affiliation></author><author><name sortKey="Gosal, David" sort="Gosal, David" uniqKey="Gosal D" first="David" last="Gosal">David Gosal</name><affiliation wicri:level="1"><nlm:aff id="aff14">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff14">Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff15">Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author><author><name sortKey="Hutchinson, Michael" sort="Hutchinson, Michael" uniqKey="Hutchinson M" first="Michael" last="Hutchinson">Michael Hutchinson</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Neurology, St Vincent's University Hospital, Dublin 4, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, St Vincent's University Hospital, Dublin 4</wicri:regionArea><wicri:noRegion>Dublin 4</wicri:noRegion></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="1"><nlm:aff id="aff17">Institute of Neurology, Catholic University, Rome 00168, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, Catholic University, Rome 00168</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="aff18">Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina, 98124 Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Pediatric Sciences, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C." last="Nichols">William C. Nichols</name><affiliation wicri:level="1"><nlm:aff id="aff20">Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea><wicri:noRegion>IN 46202</wicri:noRegion></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea><wicri:noRegion>IN 46202</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, Rachel A" sort="Gibson, Rachel A" uniqKey="Gibson R" first="Rachel A." last="Gibson">Rachel A. Gibson</name><affiliation wicri:level="1"><nlm:aff id="aff22">GlaxoSmithKline Pharmaceuticals, Research and Development, Harlow, Greenford, Hammersmith CM19 5AW, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline Pharmaceuticals, Research and Development, Harlow, Greenford, Hammersmith CM19 5AW</wicri:regionArea><wicri:noRegion>Hammersmith CM19 5AW</wicri:noRegion></affiliation></author><author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name><affiliation wicri:level="3"><nlm:aff id="aff23">Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service de Neurologie, Institut National de Neurologie, 1007 La Rabta, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="aff1">Université Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm) UMR837, Institut de Recherches sur le Cancer de Lille (IRCL), Place de Verdun, 59045 Lille Cedex, IFR114 IMPRT F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille(CHRU), Department of Neurology and Movement Disorders, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:aff id="aff3">Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224</wicri:regionArea><wicri:noRegion>FL 32224</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 2B5</wicri:regionArea><wicri:noRegion>British Columbia V6T 2B5</wicri:noRegion></affiliation></author></analytic><series><title level="j">American Journal of Human Genetics</title><idno type="ISSN">0002-9297</idno><idno type="eISSN">1537-6605</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is explained by a missense mutation c.3614G>A (p.Arg1205His) in eukaryotic translation initiation factor 4-gamma (<italic>EIF4G1</italic>). Subsequent sequence and genotype analysis identified <italic>EIF4G1</italic> c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. Despite different countries of origin, persons with <italic>EIF4G1</italic> c.1505C>T (p.Ala502Val) or c.3614G>A (p.Arg1205His) mutations appear to share haplotypes consistent with ancestral founders. eIF4G1 p.Ala502Val and p.Arg1205His disrupt eIF4E or eIF3e binding, although the wild-type protein does not, and render mutant cells more vulnerable to reactive oxidative species. <italic>EIF4G1</italic> mutations implicate mRNA translation initiation in familial parkinsonism and highlight a convergent pathway for monogenic, toxin and perhaps virally-induced Parkinson disease.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Norvège</li><li>Pologne</li><li>Royaume-Uni</li><li>Tunisie</li><li>États-Unis</li></country><region><li>Gouvernorat de Tunis</li><li>Hauts-de-France</li><li>Latium</li><li>Nord-Pas-de-Calais</li><li>Québec</li><li>Trøndelag</li></region><settlement><li>Lille</li><li>Montréal</li><li>Rome</li><li>Trondheim</li><li>Tunis</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li><li>Université McGill</li></orgName></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name></region><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><name sortKey="Duflot, Aurelie" sort="Duflot, Aurelie" uniqKey="Duflot A" first="Aurélie" last="Duflot">Aurélie Duflot</name><name sortKey="Duflot, Aurelie" sort="Duflot, Aurelie" uniqKey="Duflot A" first="Aurélie" last="Duflot">Aurélie Duflot</name><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><name sortKey="Larvor, Lydie" sort="Larvor, Lydie" uniqKey="Larvor L" first="Lydie" last="Larvor">Lydie Larvor</name><name sortKey="Larvor, Lydie" sort="Larvor, Lydie" uniqKey="Larvor L" first="Lydie" last="Larvor">Lydie Larvor</name><name sortKey="Le Rhun, Emilie" sort="Le Rhun, Emilie" uniqKey="Le Rhun E" first="Emilie" last="Le Rhun">Emilie Le Rhun</name><name sortKey="Lepretre, Frederic" sort="Lepretre, Frederic" uniqKey="Lepretre F" first="Frédéric" last="Leprêtre">Frédéric Leprêtre</name><name sortKey="Lepretre, Frederic" sort="Lepretre, Frederic" uniqKey="Lepretre F" first="Frédéric" last="Leprêtre">Frédéric Leprêtre</name><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><name sortKey="Vanbesien Mailliot, Christel" sort="Vanbesien Mailliot, Christel" uniqKey="Vanbesien Mailliot C" first="Christel" last="Vanbesien-Mailliot">Christel Vanbesien-Mailliot</name><name sortKey="Vanbesien Mailliot, Christel" sort="Vanbesien Mailliot, Christel" uniqKey="Vanbesien Mailliot C" first="Christel" last="Vanbesien-Mailliot">Christel Vanbesien-Mailliot</name><name sortKey="Vanbesien Mailliot, Christel" sort="Vanbesien Mailliot, Christel" uniqKey="Vanbesien Mailliot C" first="Christel" last="Vanbesien-Mailliot">Christel Vanbesien-Mailliot</name></country><country name="États-Unis"><noRegion><name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name></noRegion><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><name sortKey="Hentati, Emna" sort="Hentati, Emna" uniqKey="Hentati E" first="Emna" last="Hentati">Emna Hentati</name><name sortKey="Hulihan, Mary M" sort="Hulihan, Mary M" uniqKey="Hulihan M" first="Mary M." last="Hulihan">Mary M. Hulihan</name><name sortKey="Kachergus, Jennifer" sort="Kachergus, Jennifer" uniqKey="Kachergus J" first="Jennifer" last="Kachergus">Jennifer Kachergus</name><name sortKey="Keeling, Brett H" sort="Keeling, Brett H" uniqKey="Keeling B" first="Brett H." last="Keeling">Brett H. Keeling</name><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. Lincoln</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Melrose, Heather L" sort="Melrose, Heather L" uniqKey="Melrose H" first="Heather L." last="Melrose">Heather L. Melrose</name><name sortKey="Nichols, William C" sort="Nichols, William C" uniqKey="Nichols W" first="William C." last="Nichols">William C. Nichols</name><name sortKey="Nishioka, Kenya" sort="Nishioka, Kenya" uniqKey="Nishioka K" first="Kenya" last="Nishioka">Kenya Nishioka</name><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><name sortKey="Williams, Lindsey" sort="Williams, Lindsey" uniqKey="Williams L" first="Lindsey" last="Williams">Lindsey Williams</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><name sortKey="Zubair, Abba C" sort="Zubair, Abba C" uniqKey="Zubair A" first="Abba C." last="Zubair">Abba C. Zubair</name></country><country name="Canada"><noRegion><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name></noRegion><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><name sortKey="Milnerwood, Austen J" sort="Milnerwood, Austen J" uniqKey="Milnerwood A" first="Austen J." last="Milnerwood">Austen J. Milnerwood</name><name sortKey="Sonenberg, Nahum" sort="Sonenberg, Nahum" uniqKey="Sonenberg N" first="Nahum" last="Sonenberg">Nahum Sonenberg</name><name sortKey="Song, Mee Sook" sort="Song, Mee Sook" uniqKey="Song M" first="Mee-Sook" last="Song">Mee-Sook Song</name><name sortKey="Tapia, Lucia" sort="Tapia, Lucia" uniqKey="Tapia L" first="Lucia" last="Tapia">Lucia Tapia</name><name sortKey="Yanagiya, Akiko" sort="Yanagiya, Akiko" uniqKey="Yanagiya A" first="Akiko" last="Yanagiya">Akiko Yanagiya</name></country><country name="Australie"><noRegion><name sortKey="Lockhart, Paul J" sort="Lockhart, Paul J" uniqKey="Lockhart P" first="Paul J." last="Lockhart">Paul J. Lockhart</name></noRegion></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name></region></country><country name="Pologne"><noRegion><name sortKey="Krygowska Wajs, Anna" sort="Krygowska Wajs, Anna" uniqKey="Krygowska Wajs A" first="Anna" last="Krygowska-Wajs">Anna Krygowska-Wajs</name></noRegion><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gosal, David" sort="Gosal, David" uniqKey="Gosal D" first="David" last="Gosal">David Gosal</name></noRegion><name sortKey="Hutchinson, Michael" sort="Hutchinson, Michael" uniqKey="Hutchinson M" first="Michael" last="Hutchinson">Michael Hutchinson</name><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name><name sortKey="Lynch, Tim" sort="Lynch, Tim" uniqKey="Lynch T" first="Tim" last="Lynch">Tim Lynch</name></country><country name="Italie"><region name="Latium"><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></region><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Gibson, Rachel A" sort="Gibson, Rachel A" uniqKey="Gibson R" first="Rachel A." last="Gibson">Rachel A. Gibson</name></noRegion></country><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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